High risk of developing subsequent epilepsy in patients with sleep-disordered breathing.

ABSTRACT:

Purpose

Sleep-disordered breathing (SDB) is often associated with other medical disorders. Whether SDB interacts with other factors for developing subsequent epilepsy remains unclear.

Methods

This population-based cohort study was conducted using the National Health Insurance Research Database of Taiwan. Patients aged >20 years and diagnosed with SDB between 2000 and 2010 comprised the SDB cohort (n = 138,507), and their data were compared with those of the comparison cohort (n = 138,507). The adjusted hazard ratio (aHR) for epilepsy was calculated using a multivariate Cox proportional hazards model.

Results

The SDB cohort had an increased risk of epilepsy (aHR = 1.50, 95% confidence interval [CI] = 1.36-1.66). The sex-stratified analysis revealed a significant adjust

SUBMITTER: Harnod T 

PROVIDER: S-EPMC5349663 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature