Intravenous anesthetic propofol binds to 5-lipoxygenase and attenuates leukotriene B₄ production.

ABSTRACT: Propofol is an intravenous anesthetic that produces its anesthetic effect, largely via the GABA_A receptor in the CNS, and also reduces the N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced neutrophil respiratory burst. Because fMLP-stimulated neutrophils produce leukotriene (LT)B₄, we examined the effect of propofol on LTB₄ production in vivo and in vitro Cecal ligation and puncture surgery was performed in mice, with or without exposure to propofol. Propofol attenuated the production of 5-lipoxygenase (5-LOX)-related arachidonic acid (AA) derivatives in the peritoneal fluid. Also, in the in vitro experiments on fMLP-stimulated neutrophils and 5-LOX-transfected human embryonic kidney cells, propofol attenuated the pro

SUBMITTER: Okuno T 

PROVIDER: S-EPMC5349797 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature