Kidney Disease Progression in Autosomal Recessive Polycystic Kidney Disease.

ABSTRACT:

Objective

To define glomerular filtration rate (GFR) decline, hypertension (HTN), and proteinuria in subjects with autosomal recessive polycystic kidney disease (ARPKD) and compare with 2 congenital kidney disease control groups in the Chronic Kidney Disease in Children cohort.

Study design

GFR decline (iohexol clearance), rates of HTN (ambulatory/casual blood pressures), antihypertensive medication usage, left ventricular hypertrophy, and proteinuria were analyzed in subjects with ARPKD (n = 22) and 2 control groups: aplastic/hypoplastic/dysplastic disorders (n = 44) and obstructive uropathies (n = 44). Differences between study groups were examined with the Wilcoxon rank sum test.

Results

Annualized GFR change in subjects with ARPKD was -1.4 mL/min/1.73 m(2) (-6%),

SUBMITTER: Dell KM 

PROVIDER: S-EPMC5349855 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature