Discovery and replication of microRNAs for breast cancer risk using genome-wide profiling.

ABSTRACT:

Background

Genome-wide miRNA expression may be useful for predicting breast cancer risk and/or for the early detection of breast cancer.

Results

A 41-miRNA model distinguished breast cancer risk in the discovery study (accuracy of 83.3%), which was replicated in the independent study (accuracy = 63.4%, P=0.09). Among the 41 miRNA, 20 miRNAs were detectable in serum, and predicted breast cancer occurrence within 18 months of blood draw (accuracy 53%, P=0.06). These risk-related miRNAs were enriched for HER-2 and estrogen-dependent breast cancer signaling.

Materials and methods

MiRNAs were assessed in two cross-sectional studies of women without breast cancer and a nested case-control study of breast cancer. Using breast tissues, a multivariate analysis was used to mode

SUBMITTER: Taslim C 

PROVIDER: S-EPMC5349926 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature