Negative feedback between TAp63 and Mir-133b mediates colorectal cancer suppression.

ABSTRACT:

Background

TAp63 is known as the most potent transcription activator and tumor suppressor. microRNAs (miRNAs) are increasingly recognized as essential components of the p63 pathway, mediating downstream post-transcriptional gene repression. The aim of present study was to investigate a negative feedback loop between TAp63 and miR-133b.

Results

Overexpression of TAp63 inhibited HCT-116 cell proliferation, apoptosis and invasion via miR-133b. Accordingly, miR-133b inhibited TAp63 expression through RhoA and its downstream pathways. Moreover, we demonstrated that TAp63/miR-133b could inhibit colorectal cancer proliferation and metastasis in vivo and vitro.

Materials and methods

We evaluated the correlation between TAp63 and miR-133b in HCT-116 cells and investigated the

SUBMITTER: Dai J 

PROVIDER: S-EPMC5349978 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature