Identification of differentially expressed genes in the development of osteosarcoma using RNA-seq.

ABSTRACT:

Objective

Osteosarcoma (OS) is a malignant bone tumor with high morbidity in young adults and adolescents. This study aimed to discover potential early diagnosis biomarkers in OS.

Results

In total, 111 differentially expressed genes (DEGs) were identified in primary OS compared with normal controls and 235 DEGs were identified in metastatic OS compared with primary OS. AURKB and PPP2R2B were the significantly up-regulated and down-regulated hub proteins, respectively, in the PPI protein-protein network (PPI) network of primary OS. ISG15 and BTRC were the significantly up-regulated and down-regulated hub proteins, respectively, in the network of metastatic OS. The DEGs in metastatic OS compared with primary OS were significantly enriched in the arachidonic acid metabolism, ma

SUBMITTER: Yang Y 

PROVIDER: S-EPMC5349981 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature