Seeing through the smoke: Human and animal studies of cannabis use and endocannabinoid signalling in corticolimbic networks.

ABSTRACT: Public opinion surrounding the recreational use and therapeutic potential of cannabis is shifting. This review describes new work examining the behavioural and neural effects of cannabis and the endocannabinoid system, highlighting key regions within corticolimbic brain circuits. First, we consider the role of human genetic factors and cannabis strain chemotypic differences in contributing to interindividual variation in the response to cannabinoids, such as THC, and review studies demonstrating that THC-induced impairments in decision-making processes are mediated by actions at prefrontal CB₁ receptors. We further describe evidence that signalling through prefrontal or ventral hippocampal CB₁ receptors modulates mesolimbic dopamine activity, aberrations of which may

SUBMITTER: Silveira MM 

PROVIDER: S-EPMC5350061 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature