Brain white matter changes in CPAP-treated obstructive sleep apnea patients with residual sleepiness.

ABSTRACT:

Purpose

To investigate white matter (WM) structural alterations using diffusion tensor imaging (DTI) in obstructive sleep apnea (OSA) patients, with or without residual sleepiness, following adherent continuous positive airway pressure (CPAP) treatment. Possible quantitative relationships were explored between the DTI metrics and two clinical assessments of somnolence.

Materials and methods

Twenty-nine male patients (30-55 years old) with a confirmed diagnosis of OSA were recruited. The patients were treated with CPAP therapy only. The Psychomotor Vigilance Task (PVT) and Epworth Sleepiness Scale (ESS) were performed after CPAP treatment and additionally administered at the time of the magnetic resonance imaging (MRI) scan. Based on the PVT results, the patients were divided

SUBMITTER: Xiong Y 

PROVIDER: S-EPMC5350066 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature