Fasciola hepatica Immune Regulates CD11c⁺ Cells by Interacting with the Macrophage Gal/GalNAc Lectin.

ABSTRACT: Fasciolosis, caused by Fasciola hepatica and Fasciola gigantica, is a trematode zoonosis of interest in public health and livestock production. Like other helminths, F. hepatica modulates the host immune response by inducing potent polarized Th2 and regulatory T cell immune responses and by downregulating the production of Th1 cytokines. In this work, we show that F. hepatica glycans increase Th2 immune responses by immunomodulating TLR-induced maturation and function of dendritic cells (DCs). This process was mediated by the macrophage Gal/GalNAc lectin (MGL) expressed on DCs, which recognizes the Tn antigen (GalNAc-Ser/Thr) on parasite components. More interestingly, we identified MGL-expressing CD11c⁺ cells in infected animals and showed that these

SUBMITTER: Rodriguez E 

PROVIDER: S-EPMC5350155 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature