CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs.

ABSTRACT: Mitochondria are essential organelles that host crucial metabolic pathways and produce adenosine triphosphate. The mitochondrial proteome is heterogeneous among tissues and can dynamically change in response to different metabolic conditions. Although the transcriptional programs that govern mitochondrial biogenesis and respiratory function are well known, posttranscriptional regulatory mechanisms remain unclear. In this study, we show that the cytosolic RNA-binding protein clustered mitochondria homologue (CLUH) regulates the expression of a mitochondrial protein network supporting key metabolic programs required under nutrient deprivation. CLUH exerts its function by controlling the stability and translation of target messenger RNAs. In the absence of Cluh, mitochondria are severe

SUBMITTER: Schatton D 

PROVIDER: S-EPMC5350512 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature