Damage to white matter bottlenecks contributes to language impairments after left hemispheric stroke.

ABSTRACT: Damage to the white matter underlying the left posterior temporal lobe leads to deficits in multiple language functions. The posterior temporal white matter may correspond to a bottleneck where both dorsal and ventral language pathways are vulnerable to simultaneous damage. Damage to a second putative white matter bottleneck in the left deep prefrontal white matter involving projections associated with ventral language pathways and thalamo-cortical projections has recently been proposed as a source of semantic deficits after stroke. Here, we first used white matter atlases to identify the previously described white matter bottlenecks in the posterior temporal and deep prefrontal white matter. We then assessed the effects of damage to each region on measures of verbal fluency, picture namin

SUBMITTER: Griffis JC 

PROVIDER: S-EPMC5350568 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature