Odor Identification Screening Improves Diagnostic Classification in Incipient Alzheimer's Disease.

ABSTRACT:

Background

Measurements of olfaction may serve as useful biomarkers of incipient dementia. Here we examine the improvement in diagnostic accuracy of Alzheimer's disease (AD) and mild cognitive impairment (MCI) when assessing both cognitive functioning and odor identification.

Objective

To determine the utility of odor identification as a supplementary screening test in incipient AD.

Methods

Sniffin' Sticks Odor Identification Test (SS-OIT) and the Montreal Cognitive Assessment (MoCA) were administered in 262 AD, 174 MCI [150 amnestic (aMCI), and 24 non-amnestic (naMCI)], and 292 healthy older adults (HOA).

Results

Odor identification scores were higher in HOA relative to MCI or AD groups, and MCI outperformed AD. Odor identification scores were higher in aMCI s

SUBMITTER: Quarmley M 

PROVIDER: S-EPMC5350629 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature