Distinctive frequencies of +874T/A IFN-γ gene polymorphism in a healthy Serbian population.

ABSTRACT:

Purpose

Single nucleotide polymorphism (SNP) in IFN-γ gene (+874T/A) that determines high (TT), low (AA), and intermediate (TA) responder phenotypes has shown associations with susceptibility to infectious and chronic inflammatory diseases, as well as disease outcome. Therefore, the susceptibility to and outcome of certain diseases can vary in different ethnic populations partially due to the notable differences in frequencies of genotypes and alleles between them. The aim of this study was to determine the distribution of +874T/A genotype and allele frequencies in a healthy Serbian population as a reference for further disease association studies.

Materials and methods

Genomic DNA samples from 166 healthy volunteers were evaluated for IFN-γ SNP at position +874 using TaqMan

SUBMITTER: Popadic D 

PROVIDER: S-EPMC5350806 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature