In silico functional elucidation of uncharacterized proteins of Chlamydia abortus strain LLG.

ABSTRACT:

Aim

This study reports structural modeling, molecular dynamics profiling of hypothetical proteins in Chlamydia abortus genome database.

Methodology

The hypothetical protein sequences were extracted from C. abortus LLG Genome Database for functional elucidation using in silico methods.

Results

Fifty-one proteins with their roles in defense, binding and transporting other biomolecules were unraveled. Forty-five proteins were found to be nonhomologous to proteins present in hosts infected by C. abortus. Of these, 31 proteins were related to virulence. The structural modeling of two proteins, first, WP_006344020.1 (phosphorylase) and second, WP_006344325.1 (chlamydial protease/proteasome-like activity factor) were accomplished. The conserved ac

SUBMITTER: Singh G 

PROVIDER: S-EPMC5351547 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature