High expression of miR-181c as a predictive marker of recurrence in stage II colorectal cancer.

ABSTRACT:

Introduction

A standard treatment for stage II colorectal cancer (CRC) is surgical resection without adjuvant chemotherapy. However, the recurrence rate of these patients is approximately 20%. To date, there are no robust biomarkers suitable for predicting recurrence in stage II CRC patients. In this study, microRNAs (miRNAs) extracted from CRC tissues were examined for a possible biomarker to predict recurrence in stage II CRC patients.

Results

From the comprehensive analysis, 15 miRNAs were selected as candidates for further study. Regarding let-7a, -7d, -7e, miR-23c, -26b, -128a, -151-5p, and -181c, recurrence rates in training cohort patients with higher expression of these miRNAs isolated from their frozen tissues samples were significantly higher than those with lower

SUBMITTER: Yamazaki N 

PROVIDER: S-EPMC5351683 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature