Indole-fused benzooxazepines: a new structural class of anticancer agents.

ABSTRACT:

Aim

A new series of compounds (1a-16a) bearing indole-fused benzooxazepine was synthesized, characterized and evaluated for anticancer activity.

Materials & methods

In this study, all the synthesized compounds were screened via in vitro anticancer testing on Hep-G2 cancer cell line. A computational study was carried out on cancer-related targets including IL-2, IL-6, COX-2 Caspase-3 and Caspase-8.

Results

Some of the synthesized compounds effectively controlled the growth of cancerous cells.

Conclusion

The most active compounds - 6a, 10a, 13a, 14a and 15a - exemplify notable anticancer profile with GI₅₀ <10 μg/ml. Preliminary structure-activity relationship among the tested compounds can produce an ass

SUBMITTER: Singh AK 

PROVIDER: S-EPMC5351710 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature