Role of Apamin-Sensitive Calcium-Activated Small-Conductance Potassium Currents on the Mechanisms of Ventricular Fibrillation in Pacing-Induced Failing Rabbit Hearts.

ABSTRACT:

Background

Ventricular fibrillation (VF) during heart failure is characterized by stable reentrant spiral waves (rotors). Apamin-sensitive small-conductance calcium-activated potassium currents (I_KAS) are heterogeneously upregulated in failing hearts. We hypothesized that I_KAS influences the location and stability of rotors during VF.

Methods and results

Optical mapping was performed on 9 rabbit hearts with pacing-induced heart failure. The epicardial right ventricular and left ventricular surfaces were simultaneously mapped in a Langendorff preparation. At baseline and after apamin (100 nmol/L) infusion, the action potential duration (APD₈₀) was determined, and VF was induced. Areas with a >50% increase in the maximum action po

SUBMITTER: Yin D 

PROVIDER: S-EPMC5351779 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature