A numerical investigation of intrathecal isobaric drug dispersion within the cervical subarachnoid space.

ABSTRACT: Intrathecal drug and gene vector delivery is a procedure to release a solute within the cerebrospinal fluid. This procedure is currently used in clinical practice and shows promise for treatment of several central nervous system pathologies. However, intrathecal delivery protocols and systems are not yet optimized. The aim of this study was to investigate the effects of injection parameters on solute distribution within the cervical subarachnoid space using a numerical platform. We developed a numerical model based on a patient-specific three dimensional geometry of the cervical subarachnoid space with idealized dorsal and ventral nerve roots and denticulate ligament anatomy. We considered the drug as massless particles within the flow field and with similar properties as the CSF, and we a

SUBMITTER: Haga PT 

PROVIDER: S-EPMC5351861 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature