Longitudinal dynamics of the HIV-specific B cell response during intermittent treatment of primary HIV infection.

ABSTRACT:

Background

Neutralizing antibodies develop in natural HIV-1 infection. Their development often takes several years and may rely on chronic virus exposure. At the same time recent studies show that treatment early in infection may provide opportunities for immune preservation. However, it is unknown how intermittent treatment in early infection affects development of the humoral immune response over time. We investigate the effect of cART in early HIV infection on the properties of the memory B cell compartment following 6 months of cART or in the absence of treatment. The patients included participated in the Primo-SHM trial where patients with an early HIV-1 infection were randomized to no treatment or treatment for 24 or 60 weeks.

Methods

Primo-SHM trial patients selected

SUBMITTER: de Bree GJ 

PROVIDER: S-EPMC5351995 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature