Prognostic value of increased KPNA2 expression in some solid tumors: A systematic review and meta-analysis.

ABSTRACT:

Background

Karyopherin α2 (KPNA2), a member of the Karyopherin α family, has recently been reported to play an important role in tumor progression. However, the association between KPNA2 expression and prognosis in cancer remains controversial. So we performed this meta-analysis to evaluate whether expression of KPNA2 was associated with prognosis in patients with solid tumor.

Methods/findings

24 published eligible studies, including 6164 cases, were identified and included in this meta-analysis through searching of PubMed, EMBASE and Web of Science. We found that KPNA2 expression was an independent predictor for the prognosis of solid tumor with primary outcome (overall survival [OS]: pooled HR=1.767, 95% CI=1.503-2.077, P<0.001) and secondary outcomes (time to recurrence [

SUBMITTER: Zhou LN 

PROVIDER: S-EPMC5352121 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature