Transcriptome analysis of endometrial tissues following GnRH agonist treatment in a mouse adenomyosis model.

ABSTRACT:

Purpose

Adenomyosis is a common, benign gynecological condition of the female reproductive tract characterized by heavy menstrual bleeding and dysmenorrhea. Gonadotropin-releasing hormone (GnRH) agonists are one of the medications used in adenomyosis treatment; however, their underlying mechanisms are poorly understood. Moreover, it is difficult to obtain endometrial samples from women undergoing such treatment. To overcome this, we generated an adenomyosis mouse model, which we treated with an GnRH agonist to determine its effect on pregnancy outcomes. We also analyzed endometrial gene expression following GnRH agonist treatment to determine the mechanisms that may affect pregnancy outcome in individuals with adenomyosis.

Methods

Neonatal female mice were divided into a con

SUBMITTER: Guo S 

PROVIDER: S-EPMC5352156 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature