Novel risk models for early detection and screening of ovarian cancer.

ABSTRACT:

Purpose

Ovarian cancer (OC) is the most lethal gynaecological cancer. Early detection is required to improve patient survival. Risk estimation models were constructed for Type I (Model I) and Type II (Model II) OC from analysis of Protein Z, Fibronectin, C-reactive protein and CA125 levels in prospectively collected samples from the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS).

Results

Model I identifies cancers earlier than CA125 alone, with a potential lead time of 3-4 years. Model II detects a number of high grade serous cancers at an earlier stage (Stage I/II) than CA125 alone, with a potential lead time of 2-3 years and assigns high risk to patients that the ROCA Algorithm classified as normal.

Materials and methods

This nested case co

SUBMITTER: Russell MR 

PROVIDER: S-EPMC5352196 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature