Variants in the SMARCA4 gene was associated with coronary heart disease susceptibility in Chinese han population.

ABSTRACT:

Background

Coronary heart disease (CHD) is the leading cause of death worldwide. Many single-nucleotide polymorphisms (SNPs) are found to be related to the risk of CHD in previous studies. This study investigated whether polymorphism of SMARCA4 gene is associated with CHD.

Materials and methods

Genotypes at five CHD-relevant SNPs were determined in 456 cases of incident CHD and 685 unaffected controls in Chinese Han population using χ2 test, genetic model analysis and haplotype analysis. We also analysis the differences in continuous variables among the subjects with three genotypes of related genes were assessed using the ANOVA.

Results

We identified two susceptibility SNPs in the SMARCA4 gene that were potentially associated with a decreased risk of CHD. We identifi

SUBMITTER: Guo X 

PROVIDER: S-EPMC5352326 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature