Association of C5L2 genetic polymorphisms with coronary artery disease in a Han population in Xinjiang, China.

ABSTRACT:

Background

C5aR-like receptor 2 (C5L2) has been identified as a receptor for the inflammatory factor Complement 5a (C5a) and acylation-stimulating protein (ASP). ASP binding to C5L2 leading to a net accumulation of TG stores and glucose transporter. The aim of the present study is to evaluate the association of the SNPs of C5L2 gene with coronary artery disease (CAD) in a Chinese population.

Methods

We examined the role of the tagging single nucleotide polymorphisms (SNPs) of C5L2 gene for CAD using a case-control design. We determined the prevalence of C5L2 genotypes in 505 CAD patients and 469 age and sex-matched healthy control subjects of Han population.

Results

There was significant difference in genotype distributions of rs2972607 and rs8112962 between CAD patie

SUBMITTER: Zheng YY 

PROVIDER: S-EPMC5352424 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature