Electrophilic nitro-fatty acids suppress allergic contact dermatitis in mice.

ABSTRACT:

Background

Reactions between nitric oxide (NO), nitrite (NO2-), and unsaturated fatty acids give rise to electrophilic nitro-fatty acids (NO₂ -FAs), such as nitro oleic acid (OA-NO₂ ) and nitro linoleic acid (LNO₂ ). Endogenous electrophilic fatty acids (EFAs) mediate anti-inflammatory responses by modulating metabolic and inflammatory signal transduction reactions. Hence, there is considerable interest in employing NO₂ -FAs and other EFAs for the prevention and treatment of inflammatory disorders. Thus, we sought to determine whether OA-NO₂ , an exemplary nitro-fatty acid, has the capacity to inhibit cutaneous inflammation.

Methods

We evaluated the effect of OA-NO₂ on allergic contact dermatitis (ACD) using a

SUBMITTER: Mathers AR 

PROVIDER: S-EPMC5352476 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature