Severe cardiac iron toxicity in two adults with sickle cell disease.

ABSTRACT:

Background

Use of chronic blood transfusions as a treatment modality in patients with blood disorders places them at risk for iron overload. Since patients with β-thalassemia major (TM) are transfusion-dependent, most studies on iron overload and chelation have been conducted in this population. While available data suggest that compared to TM, patients with sickle cell disease (SCD) have a lower risk of extrahepatic iron overload, significant iron overload can develop. Further, previous studies have demonstrated a direct relationship between iron overload and morbidity and mortality rates in SCD. However, reports describing the outcome for patients with SCD and cardiac iron overload are rare.

Study design and methods

We performed a retrospective analysis and identified two

SUBMITTER: Oduor H 

PROVIDER: S-EPMC5352507 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature