Mathematics as a conduit for translational research in post-traumatic osteoarthritis.

ABSTRACT: Biomathematical models offer a powerful method of clarifying complex temporal interactions and the relationships among multiple variables in a system. We present a coupled in silico biomathematical model of articular cartilage degeneration in response to impact and/or aberrant loading such as would be associated with injury to an articular joint. The model incorporates fundamental biological and mechanical information obtained from explant and small animal studies to predict post-traumatic osteoarthritis (PTOA) progression, with an eye toward eventual application in human patients. In this sense, we refer to the mathematics as a "conduit of translation." The new in silico framework presented in this paper involves a biomathematical model for the cellular and biochemical response to strains

SUBMITTER: Ayati BP 

PROVIDER: S-EPMC5352510 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature