Understanding Treatment Disconnect and Mortality Trends in Renal Cell Carcinoma Using Tumor Registry Data.

ABSTRACT:

Background and objectives

The paradoxical rise in overall and cancer-specific mortality despite increased detection and treatment of renal cell carcinoma (RCC) is termed "treatment disconnect." We reassess this phenomenon by evaluating impact of missing data and rising incidence on mortality trends.

Research design, subjects, and measures

Using Surveillance, Epidemiology, and End Results data, we identified patients with RCC diagnosis from 1973 to 2011. We estimated mortality rates by tumor size after accounting for lags from diagnosis to death using multiple imputations for missing data from 1983. Mortality rates were estimated irrespective of tumor size after adjustment for prior cumulative incidence using ridge regression.

Results

A total of 78,891 patients met inc

SUBMITTER: Smaldone MC 

PROVIDER: S-EPMC5352513 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature