Validation of the prognostic value of MMP-7 in idiopathic pulmonary fibrosis.

ABSTRACT:

Background and objective

Idiopathic pulmonary fibrosis (IPF) is a progressive disease with poor prognosis and variable clinical course. Although matrix metalloproteinase-7 (MMP-7) is emerging as an important IPF biomarker, reproducibility across studies is unclear. We aimed to determine whether a previously reported prognostic threshold for MMP-7 was predictive of mortality in an independent cohort of IPF patients.

Methods

MMP-7 concentrations obtained from heparinized plasma samples were determined by ELISA in 97 patients with IPF and 41 healthy controls. The association of the previously published heparin plasma MMP-7 threshold of 12.1 ng/mL with all-cause mortality or transplant-free survival (TFS) was determined, either as an independent biomarker or as part of the modif

SUBMITTER: Tzouvelekis A 

PROVIDER: S-EPMC5352520 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature