Psychophysiological endophenotypes to characterize mechanisms of known schizophrenia genetic loci.

ABSTRACT:

Background

Endophenotypes are laboratory-based measures hypothesized to lie in the causal chain between genes and clinical disorder, and to serve as a more powerful way to identify genes associated with the disorder. One promise of endophenotypes is that they may assist in elucidating the neurobehavioral mechanisms by which an associated genetic polymorphism affects disorder risk in complex traits. We evaluated this promise by testing the extent to which variants discovered to be associated with schizophrenia through large-scale meta-analysis show associations with psychophysiological endophenotypes.

Method

We genome-wide genotyped and imputed 4905 individuals. Of these, 1837 were whole-genome-sequenced at 11× depth. In a community-based sample, we conducted targeted tests o

SUBMITTER: Liu M 

PROVIDER: S-EPMC5352523 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature