Vitamin D deficiency is associated with an oxidized plasma cysteine redox potential in critically Ill children.

ABSTRACT: Critically ill populations incur high levels of oxidative stress and commonly present with vitamin D deficiency. This study aimed to investigate the relationship between vitamin D status and plasma markers of glutathione (GSH) and cysteine (Cys) redox and immunity in critically ill children. This was a cross-sectional study of n=50 PICU patients. Subjects were categorized according to their plasma 25-hydroxyvitamin D [25(OH)D] concentrations: (<20, 20-30, and ≥30ng/dL). Plasma GSH, glutathione disulfide (GSSG), Cys, and cystine (CySS) were measured with high-performance liquid chromatography, and their associated redox potentials determined (E_hGSSG and E_hCySS, respectively). Plasma LL-37, an indicator of innate immune function, was assayed with ELISA. Data were analyz

SUBMITTER: Alvarez JA 

PROVIDER: S-EPMC5352547 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature