Investigation of the Possible Role of the Hippo/YAP1 Pathway in Asthma and Allergy.

ABSTRACT:

Purpose

Several lines of evidence indicate that the Hippo/Yes-associated protein 1 (YAP1) pathways might play a role in the pathogenesis of asthma. To investigate the possible role of the Hippo/YAP1 pathway in the pathogenesis of asthma or its phenotypes.

Methods

The levels of gene expressions of the members of the Hippo/YAP1 were compared. The presence of the proteins of the YAP1 and FRMD6 were analyzed with Western blot in induced sputum of 18 asthmatic subjects and 10 control subjects. Fourteen single nucleotide polymorphisms (SNPs) in the YAP1 gene were genotyped in 522 asthmatic subjects and 711 healthy controls. The results were evaluated with traditional frequentist methods and with Bayesian network-based Bayesian multilevel analysis of relevance (BN-BMLA).

Results

SUBMITTER: Fodor LE 

PROVIDER: S-EPMC5352576 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature