An automated voxel-based method for calculating the reference value for a brain tumour metabolic index using ¹⁸F-FDG-PET and ¹¹C-methionine PET.

ABSTRACT:

Objective

The tumour-to-normal ratio (T/N) is a representative index reflecting brain tumour activity by ¹⁸F-fluorodeoxyglucose (FDG) and ¹¹C-methionine (MET) PET. We proposed a new automated method of calculating the normal reference value (N-value) for use as the denomination of T/N. This method uses voxel-based analysis of FDG- and MET-PET images. We compared the results of this method with those of the standard region-of-interest (ROI) method.

Methods

Data sets were obtained from 32 patients with newly diagnosed glioma and 13 patients with recurrent brain tumour. Our methods were as follows: (1) FDG-PET and MET-PET images were co-registered. (2) The areas where the FDG uptake was higher than a set threshold were selected. (3) For the corresponding a

SUBMITTER: Takahashi M 

PROVIDER: S-EPMC5352759 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature