Elevated cytomegalovirus IgG antibody levels are associated with HIV-1 disease progression and immune activation.

ABSTRACT:

Objective

To assess the association between cytomegalovirus (CMV) IgG antibody levels, HIV disease progression, and immune activation markers.

Design

A prospective cohort study was conducted among women enrolled in a trial that was designed to determine the effect of acyclovir on HIV disease progression in Rakai, Uganda.

Methods

The primary endpoints were progression to a CD4 T-cell count less than 250 cells/μl, nontraumatic death, or initiation of antiretroviral therapy (ART). CD4 T-cell counts, HIV viral load, C-reactive protein (CRP), and soluble CD14 levels were assessed biannually for 24 months. CMV IgG antibodies were measured at baseline among all women and annually among a subset of women who initiated ART.

Results

There were 300 HIV/CMV-coinfected part

SUBMITTER: Patel EU 

PROVIDER: S-EPMC5352830 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature