Effect of season and sunlight on viral kinetics during hepatitis C virus therapy.

ABSTRACT:

Background and aims

Rapid viral response (RVR) during antiviral treatment for hepatitis C virus (HCV) predicts sustained viral response (SVR). Recently, vitamin D levels have been associated with SVR. As sunlight is the most important source of vitamin D and shows seasonal variation, we evaluated the effect of season on viral kinetics during peginterferon/ribavirin-based therapy for HCV.

Methods

Consecutive HCV patients treated with peginterferon/ribavirin and boceprevir/ telaprevir (June 2011-July 2014) were included. Patients were grouped according to season when therapy was initiated (Season A: May-October and Season B: November-April) depending on hours of daily sunlight. Multiple logistic regression analysis included factors known to influence SVR to treatment. The depe

SUBMITTER: Hernandez-Alvarez N 

PROVIDER: S-EPMC5353279 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature