White Matter Repair After Extracellular Vesicles Administration in an Experimental Animal Model of Subcortical Stroke.

ABSTRACT: Mesenchymal stem cells have previously been shown to mediate brain repair after stroke; they secrete 50-100 nm complexes called extracellular vesicles (EVs), which could be responsible for provoking neurovascular repair and functional recovery. EVs have been observed by electron microscopy and NanoSight, and they contain associated proteins such as CD81 and Alix. This purified, homogeneous population of EVs was administered intravenously after subcortical stroke in rats. To evaluate the EVs effects, we studied the biodistribution, proteomics analysis, functional evaluation, lesion size, fiber tract integrity, axonal sprouting and white matter repair markers. We found that a single administration of EVs improved functional recovery, fiber tract integrity, axonal sprouting and white matter r

SUBMITTER: Otero-Ortega L 

PROVIDER: S-EPMC5353554 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature