Practical whole-tooth restoration utilizing autologous bioengineered tooth germ transplantation in a postnatal canine model.

ABSTRACT: Whole-organ regeneration has great potential for the replacement of dysfunctional organs through the reconstruction of a fully functional bioengineered organ using three-dimensional cell manipulation in vitro. Recently, many basic studies of whole-tooth replacement using three-dimensional cell manipulation have been conducted in a mouse model. Further evidence of the practical application to human medicine is required to demonstrate tooth restoration by reconstructing bioengineered tooth germ using a postnatal large-animal model. Herein, we demonstrate functional tooth restoration through the autologous transplantation of bioengineered tooth germ in a postnatal canine model. The bioengineered tooth, which was reconstructed using permanent tooth germ cells, erupted into the jawbone after au

SUBMITTER: Ono M 

PROVIDER: S-EPMC5353657 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature