Network reconstruction of the mouse secretory pathway applied on CHO cell transcriptome data.

ABSTRACT:

Background

Protein secretion is one of the most important processes in eukaryotes. It is based on a highly complex machinery involving numerous proteins in several cellular compartments. The elucidation of the cell biology of the secretory machinery is of great importance, as it drives protein expression for biopharmaceutical industry, a 140 billion USD global market. However, the complexity of secretory process is difficult to describe using a simple reductionist approach, and therefore a promising avenue is to employ the tools of systems biology.

Results

On the basis of manual curation of the literature on the yeast, human, and mouse secretory pathway, we have compiled a comprehensive catalogue of characterized proteins with functional annotation and their interconnectivit

SUBMITTER: Lund AM 

PROVIDER: S-EPMC5353859 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature