Interaction of CD14 haplotypes and soluble CD14 on pulmonary function in agricultural workers.

ABSTRACT:

Background

Agricultural environments are contaminated with organic dusts containing bacterial components. Chronic inhalation of organic dusts is implicated in respiratory diseases. CD14 is a critical receptor for gram-negative lipopolysaccharide; however, its association with respiratory disease among agricultural workers is unknown. The objective of this study was to determine if serum soluble CD14 (sCD14) levels are associated with lung function among agricultural workers and if this association is modified by genetic variants in CD14.

Methods

This cross-sectional study included 584 veterans with >2 years of farming experience and that were between the ages of 40 and 80 years. Participants underwent spirometry and were genotyped for four tagging CD14 polymorphisms (CD14/-2

SUBMITTER: LeVan TD 

PROVIDER: S-EPMC5353891 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature