Immunosurveillance and immunoediting in MMTV-PyMT-induced mammary oncogenesis.

ABSTRACT: Evidence of cancer immunosurveillance and immunoediting processes has been primarily demonstrated in mouse models of chemically induced oncogenesis. Although these models are very tractable, they are characterized by high mutational loads that represent a minority of human cancers. In this study, we sought to determine whether cancer immunosurveillance and immunoediting could be demonstrated in a more clinically relevant oncogene-induced model of carcinogenesis, the MMTV-PyMT (PyMT) mammary carcinoma model. This model system in the FVB/NJ strain background was previously used to demonstrate that adaptive immunity had no role in limiting primary cancer formation and in fact promoted metastasis, thus calling into question whether cancer immunosurveillance operated in preventing the developme

SUBMITTER: Gross ET 

PROVIDER: S-EPMC5353915 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature