The Canine POMC Gene, Obesity in Labrador Retrievers and Susceptibility to Diabetes Mellitus.

ABSTRACT:

Background

Diabetes mellitus (DM) in dogs is a common endocrinopathy with a complex genetic architecture. Disease susceptibility in several breeds is associated with polymorphisms in immune response genes, but in the Labrador retriever breed, no genetic associations with DM have been identified. A deletion in the pro-opiomelanocortin (POMC) gene in Labrador retrievers is associated with increased appetite and risk of obesity.

Hypothesis/objectives

To characterize the POMC deletion in Labrador retrievers, to develop a simple genetic test for this mutation, and to test the hypothesis that the POMC gene deletion is associated with an increased risk of DM in this breed.

Animals

Sixty-one non-diabetic Labrador retrievers aged >6 years and 57 Labrador retrievers with DM.

SUBMITTER: Davison LJ 

PROVIDER: S-EPMC5354034 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature