Fat2 and Lar Define a Basally Localized Planar Signaling System Controlling Collective Cell Migration.

ABSTRACT: Collective migration of epithelial cells underlies diverse tissue-remodeling events, but the mechanisms that coordinate individual cell migratory behaviors for collective movement are largely unknown. Studying the Drosophila follicular epithelium, we show that the cadherin Fat2 and the receptor tyrosine phosphatase Lar function in a planar signaling system that coordinates leading and trailing edge dynamics between neighboring cells. Fat2 signals from each cell's trailing edge to induce leading edge protrusions in the cell behind, in part by stabilizing Lar's localization in these cells. Conversely, Lar signals from each cell's leading edge to stimulate trailing edge retraction in the cell ahead. Fat2/Lar signaling is similar to planar cell polarity signaling in terms of sub-cellular prote

SUBMITTER: Barlan K 

PROVIDER: S-EPMC5354100 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature