Genetics of stroke in a UK African ancestry case-control study: South London Ethnicity and Stroke Study.

ABSTRACT:

Objective

Despite epidemiologic data showing an increased stroke incidence in African ancestry populations, genetic studies in this group have so far been limited, and there has been little characterization of the genetic contribution to stroke liability in this population, particularly for stroke subtypes.

Methods

We evaluated the evidence that genetic factors contribute to stroke and stroke subtypes in a population of 917 African and African Caribbean stroke cases and 868 matched controls from London, United Kingdom. We (1) estimated the heritability of stroke in this population using genomic-relatedness matrix-restricted maximum likelihood approaches, (2) assessed loci associated with stroke in Europeans in our population, and (3) evaluated the influence of genetic factor

SUBMITTER: Traylor M 

PROVIDER: S-EPMC5354108 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature