Probuphine® (buprenorphine implant): a promising candidate in opioid dependence.

ABSTRACT: Opioid dependence leads to physical dependence and addiction which finally results in profound medical, psychological and social dysfunction. One of the useful medications for opioid dependence is buprenorphine, the partial opioid agonist, which is used alone or in combination with naloxone. However, buprenorphine is the victim of its own success due to its illicit use and accidental poisoning in children. Also, buprenorphine typically requires daily self-administration and its effectiveness heavily depends on patient adherence. So, poor treatment adherence results in ineffective treatment manifesting as craving and withdrawal symptoms. Short-term use of buprenorphine in opioid dependence is also often followed by relapse. Buprenorphine when used sublingually often results in inadequate or

SUBMITTER: Barnwal P 

PROVIDER: S-EPMC5354129 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature