TP53 alterations in primary and secondary Sezary syndrome: A diagnostic tool for the assessment of malignancy in patients with erythroderma.

ABSTRACT: Recent massive parallel sequencing data have evidenced the genetic diversity and complexity of Sézary syndrome mutational landscape with TP53 alterations being the most prevalent genetic abnormality. We analyzed a cohort of 35 patients with SS and a control group of 8 patients with chronic inflammatory dermatoses. TP53 status was analyzed at different clinical stages especially in 9 patients with a past-history of mycosis fungoides (MF), coined secondary SS. TP53 mutations were only detected in 10 patients with either primary or secondary SS (29%) corresponding to point mutations, small insertions and deletions which were unique in each case. Interestingly, TP53 mutations were both detected in sequential unselected blood mononuclear cells and in skin specimens. Cytogenetic analysis of bloo

SUBMITTER: Gros A 

PROVIDER: S-EPMC5354275 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature