Rainbow Enhancers Regulate Restrictive Transcription in Teleost Green, Red, and Blue Cones.

ABSTRACT: Photoreceptor-specific transcription of individual genes collectively constitutes the transcriptional profile that orchestrates the structural and functional characteristics of each photoreceptor type. It is challenging, however, to study the transcriptional specificity of individual photoreceptor genes because each gene's distinct spatiotemporal transcription patterns are determined by the unique interactions between a specific set of transcription factors and the gene's own cis-regulatory elements (CREs), which remain unknown for most of the genes. For example, it is unknown what CREs underlie the zebrafish mpp5b^ponli (ponli) and crumbs2b (crb2b) apical polarity genes' restrictive transcription in the red, green, and blue (RGB) cones in the r

SUBMITTER: Fang W 

PROVIDER: S-EPMC5354330 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature