Cyclooxygenase-2 expression is positively associated with lymph node metastasis in nasopharyngeal carcinoma.

ABSTRACT:

Background

Accumulating evidence has demonstrated that cyclooxygenase-2 (COX-2) is involved in head and neck cancers, especially in nasopharyngeal carcinoma (NPC). However, the association between COX-2 expression and lymph node metastasis in NPC remains uncertain. This systematic review and meta-analysis meta-analysis investigated the relationship between COX-2 expression and lymph node metastasis and other signs of disease progression in NPC.

Methods

Previously published studies assessing COX-2 expression and lymph node metastasis in NPC were identified in four English databases and three Chinese ones (Pubmed, Embase, Cochrane Database of Systematic Reviews, Web of Science, China National Knowledge Infrastructure, Wanfang, Vip Journal Integration Platform) up to November 2

SUBMITTER: Yang G 

PROVIDER: S-EPMC5354404 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature