Parenteral metoclopramide for acute migraine: meta-analysis of randomised controlled trials.

ABSTRACT:

Objective

To assess the evidence from controlled trials on the efficacy and tolerability of parenteral metoclopramide for acute migraine in adults.

Data sources

Cochrane Central Register of Controlled Trials, Medline, Embase, LILACS, CINAHL, conference proceedings, clinical practice guidelines, and other sources.

Selection criteria

Randomised controlled trials of parenteral metoclopramide for acute migraine in adults.

Results

We reviewed 596 potentially relevant abstracts and found 13 eligible trials totalling 655 adults. In studies comparing metoclopramide with placebo, metoclopramide was more likely to provide significant reduction in migraine pain (odds ratio 2.84, 95% confidence interval 1.05 to 7.68). Used as the only agent, metoclopramide showed mixed eff

SUBMITTER: Colman I 

PROVIDER: S-EPMC535449 | biostudies-literature | 2004 Dec

REPOSITORIES: biostudies-literature