The role of non-rapid eye movement slow-wave activity in prefrontal metabolism across young and middle-aged adults.

ABSTRACT: Electroencephalographic slow-wave activity (0.5-4 Hz) during non-rapid eye movement (NREM) sleep is a marker for cortical reorganization, particularly within the prefrontal cortex. Greater slow wave activity during sleep may promote greater waking prefrontal metabolic rate and, in turn, executive function. However, this process may be affected by age. Here we examined whether greater NREM slow wave activity was associated with higher prefrontal metabolism during wakefulness and whether this relationship interacted with age. Fifty-two participants aged 25-61 years were enrolled into studies that included polysomnography and a (18) [F]-fluoro-deoxy-glucose positron emission tomography scan during wakefulness. Absolute and relative measures of NREM slow wave activity were assessed. Semiquanti

SUBMITTER: Wilckens KA 

PROVIDER: S-EPMC5354539 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature