Association of NR1I2 gene polymorphisms and time of progression to AIDS.

ABSTRACT:

Background

The time of progression towards AIDS can vary greatly among seropositive patients, and may be associated with host genetic variation. The NR1I2 (PXR) gene, a ligand-activated transcription factor, regulates the transcription immune pathway genes and can therefore be targets of viral replication mechanisms influencing time of progression to AIDS.

Objective

To verify the association of single nucleotide polymorphisms (SNPs) rs3814057, rs6785049, rs7643645, and rs2461817 in the NR1I2 (PXR) gene with progression to AIDS in HIV-1 infected patients.

Methods

Blood samples were obtained from 96 HIV-1 positive individuals following informed consent. DNA was isolated and genotyped through real time polymerase chain reaction (PCR) for the presence of SNPs in the NR1I2

SUBMITTER: Medeiros RM 

PROVIDER: S-EPMC5354613 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature